Crunchy Sound after some minutes playing

Good morning everyone, I have a problem and maybe somebody have had something similar before.

I’ve been using Djay for many years with a reloop beatpad without issues, now i just replaced my DJ hardware and the sound started to sound crunchy after 10 to 15 minutes playing (not always).

Laptop:
Macbook Pro 15 inches, late 2013, Intel Core i7 (4 cores) + 8gb RAM + Intel Iris Pro 1536MB + 256gb SSD

OS:
11.7.10 (Big Sur)

Software: Djay 5.2.4 using “beatport” account and “Neural Mix EQ” in the mixer

External Devices:
1 x Reloop RMX-95 (firmware v1.01)

2 x Denon LC6000

The two LC6000 are connected by USB to the RMX-95 (USB Hub 2 & 3 ports) and the RMX-95 are connected to the Macbook with 1 x USB cable (all cables are the original ones)

The OSx is not running any other app when using Djay Pro, the first 5 to 15 minutes the sound is OK, I’m using “Neural Mix EQ” and Mixer effects intensively during this time, after that the sound started to sound crunchy and the only way to solve is to close Djay and reopen or to restart the laptop.

Link to the video showing the problem: https://youtu.be/vUZLpRiF_ro

Thanks in advance